Treatment with Met-RANTES decreases bacterial translocation in experimental colitis - 17/08/11
, Erdogan Sozuer, M.D. a, Sebnem Gursoy, M.D. b, Ozlem Canoz, M.D. c, Tarık Artıs, M.D. a, Alper Akcan, M.D. a, Hızır Akyıldız, M.D. a, Sebahattin Muhtaroglu, M.D. d
Corresponding author. Tel.: +1-90-532-303-1922; fax: +1-90-352-437-4912.Abstract |
Background |
During colitis, epithelial function is impaired, leading to increased bacterial translocation. Recent studies have shown the important role of proinflammatory cytokines and chemokines, including RANTES (regulated on activation, normal T-cell expressed and secreted), in inflammatory bowel diseases (IBDs). In this study, we evaluated the role of Met-RANTES, an antagonist of the RANTES receptor, on the impairment of bacterial translocation in a rat model of colitis.
Methods |
Rats were randomly assigned to 3 groups. group 1 = control, group 2 = experimental colitis, and group 3 = colitis plus Met-RANTES treatment. On day 7 after colitis was induced, plasma tumor necrosis factor-⍺ colon tissue myeloperoxidase and portal blood endotoxin levels were measured. Lymph node, liver, and spleen culture quantified bacterial translocation.
Results |
Met-RANTES treatment resulted in significant decreases in colonic damage as well as bacterial translocation in experimental colitis.
Conclusions |
These results suggest that chemokine receptor antagonists may potentially be useful in the treatment of IBDs.
Le texte complet de cet article est disponible en PDF.Keywords : Bacterial translocation, Colitis, Cytokine, Experimental, RANTES
Plan
Vol 191 - N° 1
P. 77-83 - janvier 2006 Retour au numéro
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