Current concepts for the surgical management of carotid body tumor - 17/08/11
, Jose Andres Gonzalez, M.D. a, John M. Rary, Ph.D. b, Daniel S. Rush, M.D. a
Corresponding author. Tel.: +1-423-439-6771; fax: +1-423-439-6259Abstract |
Background |
Carotid body tumor (CBT) is a rare lesion of the neuroendocrine system. Chronic hypoxia has long been recognized as an etiology of CBT and other paragangliomas. Recent biogenetic discoveries reveal that mutations in oxygen-sensing genes are another etiology, accounting for approximately 35% of cases, and that these 2 etiologies are probably additive.
Data Sources |
(1) A retrospective analysis of fifteen cases of CBT in a 6-year period occurring in the mountains of Southern Appalachia; (2) an extensive review of the literature on the surgery of CBT and on the expansive biogenetic understanding of the disease.
Conclusions |
Improved imaging, vascular surgical techniques, and understanding of the disease have vastly improved outcomes for patients. The necessities for long-term follow-up and appropriate genetic testing and counseling of patients and their families are documented. Surgeon and institutional competence are critical in achieving maximal outcomes.
Le texte complet de cet article est disponible en PDF.Keywords : Carotid body tumor, Surgery, Radiation therapy, Hypoxia, Heritable, Malignant, Moderate altitudes
Plan
Vol 191 - N° 1
P. 104-110 - janvier 2006 Retour au numéro
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