The contribution of opiate analgesics to the development of infectious complications in burn patients - 17/08/11

Doi : 10.1016/j.amjsurg.2006.01.001

Martin G. Schwacha, Ph.D. ^a,^⁎ , Gerald McGwin, Ph.D. ^b,^c, Charles B. Hutchinson, B.A. ^b, James M. Cross, M.D. ^b, Paul A. MacLennan, Ph.D. ^b, Loring W. Rue, M.D. ^b
^a Center for Surgical Research and Departments of Surgery, Microbiology, and Pathology, University of Alabama at Birmingham, G094 Volker Hall, 1670 University Blvd., Birmingham, AL 35294-0019, USA
^b Center for Injury Sciences, Section of Trauma, Burns, and Surgical Critical Care, Division of General Surgery, Department of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
^c Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA

Corresponding author. Tel.: +1-205-975-9713; fax: +1-205-975-9715.

Abstract

Background

Immune and infectious complications are associated with burn injury. Opiate analgesics also can induce similar complications, however, their impact on postburn infectious complications is unknown.

Methods

A retrospective survey of records from 1997 to 2002 from an academic burn center was conducted. Information on all opiate analgesic use was obtained and expressed as opiate equivalents (OEs). Total OEs were summed for each patient and then compared between cases and controls.

Results

Patients who developed infections were more likely to be in the high OE group. This association was modified by burn severity. Patients with small burns and infection were more likely to be in the high OE group, whereas patients with moderate to large burns and infections were not associated significantly with opiate use.

Conclusions

The results of this preliminary study suggest that opiate analgesics can contribute to the development of postburn infectious complications when the burn injury is of a less severe nature.

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Keywords : Morphine, Immunosuppression, Sepsis

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Characterization of opiate analgesic use

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Vol 192 - N° 1

P. 82-86 - juillet 2006 Retour au numéro

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The contribution of opiate analgesics to the development of infectious complications in burn patients - 17/08/11

Abstract

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