Innate immune defects in atopic dermatitis - 17/08/11
Reprint requests: Lisa A. Beck, MD, Johns Hopkins University, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Rm 3A62, Baltimore, MD 21224.Baltimore, Md
Abstract |
Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that becomes clinically apparent in the pediatric population. It is well recognized that subjects with AD have an increased susceptibility to cutaneous colonization and infection with bacteria, fungi, and viruses. The notion that subjects with AD have a cutaneous immune defect has received widespread acceptance, and several plausible explanations for this have been proposed. We will review the evidence that this susceptibility to cutaneous infection is at least in part due to a defect in the first line of defense against microbes, namely the innate immune system.
Le texte complet de cet article est disponible en PDF.Key words : Atopic dermatitis, eczema, innate immunity
Abbreviations used : AD, AMP, CRTH2, GR, HBD, HSV, IL-IR, LL-37, LTA, MBL, NOD, PAMP, PGN, PGRP, PMN, PRR, SC, sCD14, TLR, VV
Plan
| Supported by grant N01 AI40029. Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 118 - N° 1
P. 202-208 - juillet 2006 Retour au numéro
Article précédent
- Management of sleep disturbance associated with atopic dermatitis
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- How epidemiology has challenged 3 prevailing concepts about atopic dermatitis
- Hywel Williams, Carsten Flohr
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