Genital HIV-1 viral load is correlated with blood plasma HIV-1 viral load in Brazilian women and is reduced by antiretroviral therapy - 17/08/11
Corresponding author. Address: Rua Almirante Alexandrino 3780/E3/302, 20241-262 Rio de Janeiro, Brazil. Tel.: +55 21 22703114; fax: +55 21 25901615.Summary |
Context |
Cervicovaginal secretions represent the primary vehicle in mother to infant and sexual HIV-1 transmission. Understanding the viral dynamics in this compartment is important to improve interventions to decrease HIV transmission.
Objectives |
To evaluate the correlation of HIV-1 blood plasma viral load and cervicovaginal HIV-1 viral load and the effect of antiretroviral therapy (ART) on cervicovaginal HIV-1 viral load.
Methods |
A cross-sectional study among HIV-1 infected women recruited between February 2002 and January 2003 and a longitudinal study that included 11 women who initiated ART were performed. HIV-1 viral load was measured in the female genital tract and in blood plasma using the Nuclisens® assay before and 1 month after ART introduction.
Results |
HIV-1 viral load in cervicovaginal lavage was significantly correlated with HIV-1 blood plasma viral load (n=27, Spearman ρ=0.73, p<0.001). In the longitudinal study, antiretroviral therapy was associated with a reduction of 1.44 log10 on genital HIV-1 viral load (95% CI=0.57–2.30, p=0.004, Student’s t-test).
Conclusions |
HIV-1 viral load in female genital secretions is correlated with blood plasma HIV-1 viral load. Antiretroviral therapy substantially reduces HIV-1 viral load in the female genital tract.
Le texte complet de cet article est disponible en PDF.Keywords : HIV-1 viral load, Cervicovaginal lavage, Antiretroviral therapy
Plan
Vol 52 - N° 4
P. 290-293 - avril 2006 Retour au numéro
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