Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease - 16/08/11
, Frank Esper b, Carla Weibel b, David Ferguson d, Marie L. Landry d, Jeffrey S. Kahn b, e
Corresponding author. Department of Internal Medicine, Infectious Diseases Section and Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Tel.: +1 203 932 5711x4225; fax: +1 203 937 4926.Summary |
Objective |
Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD.
Methods |
The study was designed as an observational cohort study carried out in a 944-bed urban teaching hospital located in New Haven, Connecticut. Between December 2002 and May 2003, patients hospitalized due to an exacerbation of COPD were identified. Nasopharyngeal specimens obtained from these patients were tested for human metapneumovirus by RT–PCR and for respiratory syncytial virus, influenza A and B, parainfluenza-1, -2, and -3 and adenovirus by a cytospin-enhanced direct immunofluorescence assay and/or viral culture.
Results |
Fifty individuals met enrollment criteria and hMPV was identified in 6 (12%), respiratory syncytial virus in 4 (8%), influenza A in 2 (4%) and parainfluenza type 3 in 1 (2%) patients. Both A and B hMPV genotypes were identified in patients hospitalized due to exacerbations of COPD.
Conclusion |
hMPV was frequently identified in patients hospitalized due to an exacerbation of COPD. Further studies are necessary to determine the epidemiology and the impact of hMPV in COPD patients.
Le texte complet de cet article est disponible en PDF.Keywords : Metapneumovirus, Lung disease, Obstructive lung disease, Paramyxoviridae infection
Plan
 | Presented in part at the 42nd Infectious Diseases Society of America Annual Meeting, Boston, MA, September 30 to October 3, 2004; Abstract 985. |
Vol 53 - N° 4
P. 248-254 - octobre 2006 Retour au numéro
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