Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology - 16/08/11

Doi : 10.1016/S1470-2045(07)70378-9

Hans Wildiers, Dr, ProfMD ^a,^⁎ , Ian Kunkler, FRCPE ^b, Laura Biganzoli, MD ^c, Jacques Fracheboud, MD ^d, George Vlastos, ProfMD ^e, Chantal Bernard-Marty, MD ^f, Arti Hurria, MD ^g, Martine Extermann, ProfMD ^h, Véronique Girre, MD ⁱ, Etienne Brain, MD ^j, Riccardo A Audisio, FRSC ^k, Harry Bartelink, ProfMD ^l, Mary Barton, MD ^m, Sharon H Giordano, MD ⁿ, Hyman Muss, MD ^o, Matti Aapro, MD ^p

^a Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium

^b Edinburgh Cancer Centre, University of Edinburgh, Edinburgh, UK

^c Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy

^d Department of Public Health, Erasmus University Medical Centre, Rotterdam, Netherlands

^e Senology and Surgical Gynecologic Unit, Geneva University Hospitals, Geneva, Switzerland

^f Medical Oncology Clinic, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium

^g Division of Medical Oncology and Experimental Therapeutics, City of Hope, Duarte, CA, USA

^h H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

ⁱ Department of Medical Oncology, Institut Curie, Paris, France

^j Medical Oncology, René Huguenin Cancer Centre, Saint-Cloud, France

^k University of Liverpool, Whiston Hospital, Prescot, UK

^l Department of Radiotherapy, Netherlands Cancer Institute, Amsterdam, Netherlands

^m Agency for Healthcare Research and Quality, Rockville, MD, USA

ⁿ Department of Breast Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA

^o Hematology Oncology Unit, University of Vermont and Vermont Cancer Center, Burlington, VT, USA

^p Institut Multidisciplinaire d’Oncologie, Clinique de Genolier, Genolier, Switzerland

^* Correspondence to: Dr Hans Wildiers, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven B-3000, Belgium

Summary

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in women worldwide. Elderly individuals make up a large part of the breast cancer population, and there are important specific considerations for this population. The International Society of Geriatric Oncology created a task force to assess the available evidence on breast cancer in elderly individuals, and to provide evidence-based recommendations for the diagnosis and treatment of breast cancer in such individuals. A review of the published work was done with the results of a search on Medline for English-language articles published between 1990 and 2007 and of abstracts from key international conferences. Recommendations are given on the topics of screening, surgery, radiotherapy, (neo)adjuvant hormone treatment and chemotherapy, and metastatic disease. Since large randomised trials in elderly patients with breast cancer are scarce, there is little level I evidence for the treatment of such patients. The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults.

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Vol 8 - N° 12

P. 1101-1115 - décembre 2007 Retour au numéro

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Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology - 16/08/11

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