5. IgE, mast cells, basophils, and eosinophils - 15/08/11
Reprint requests: Dean D. Metcalfe, MD, NIH/NIAID/LAD, Building 10, Room 11C205, 10 Center Dr, MSC 1881, Bethesda, MD 20892-1881.Bethesda, MdThis activity is available for CME credit. See page 5A for important information.
Abstract |
IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to Fc
RI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.
Key words : IgE, IgE receptor, mast cell, basophil, eosinophil
Abbreviations used : APC, ITAM, LT, MBP, PG, SCF, STAT, TLR
Plan
| The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health. |
Vol 117 - N° 2S2
P. S450-S456 - février 2006 Retour au numéro
Article précédent
- 4. Autoimmunity, vasculitis, and autoantibodies
- Susan J. Lee, Arthur Kavanaugh
- 6. Asthma: Factors underlying inception, exacerbation, and disease progression
- Robert F. Lemanske, William W. Busse
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?