Celiac disease is estimated to occur in about 1% of the population. The disease is usually diagnosed by serologic testing which leads to endoscopic duodenal biopsy. Because of the specificity of the visual endoscopic markers of celiac disease, capsule endoscopy may replace endoscopy and biopsy in selected patients. Characteristic endoscopic findings in the duodenum for patients who have celiac disease include reduced duodenal folds; scalloping of folds; mucosal fissures, crevices, or grooves; mosaic pattern and visible submucosal vessels. Additional studies are needed to determine the role of capsule endoscopy in the diagnosis and management of celiac disease.