The European experience of wireless capsule endoscopy (WCE) in Crohn’s disease (CD) is presented. Evidence from prospective studies comparing WCE with standard methods speaks in favor of WCE as the method with the highest sensitivity for diagnosing small intestinal CD. WCE is likely to be helpful in diagnosing CD, in determining the extent of the disease, and in providing information on which of the current treatment approaches are specifically effective within the small intestine. Although the invention of the patency capsule was helpful for diagnosing and characterizing small bowel strictures, the problem of capsule retention in CD patients remains a controversial issue.