Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis - 15/08/11

Doi : 10.1016/j.tube.2007.08.005

Pamaree Billamas ^a, Nat Smittipat ^a, Tada Juthayothin ^a, Arunee Thong-On ^a,^{^{1
Present address: College of Medicine and Public Health, Ubon Rajathanee University, Ubon Rajathanee, Thailand.}}, Norio Yamada ^c,^{^{2
Present address: Nagasaki University, Nagasaki, Japan.}}, Hideki Yanai ^c,^{^{2
Present address: Nagasaki University, Nagasaki, Japan.}}, Prasit Palittapongarnpim ^a,^b,^⁎
^a National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, Thailand
^b Department of Microbiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
^c Epidemiology Division, The Research Institute of Tuberculosis (RIT), Matsuyama, Kiyose, Tokyo, Japan

Corresponding author. Department of Microbiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. Tel.: +6625646700x3444; fax: +6626445411.

Summary

The patterns of variable-number tandem repeats (VNTR) genotypes of a clonal group of Mycobacterium tuberculosis Beijing isolates with very similar IS6110-restriction fragment length polymorphism (RFLP) patterns were studied. Differences between VNTR were mostly by a single repeat unit. However, a multiple-unit change also occurred. This suggests that a mechanism other than the slipped-strand mispairing might be responsible for the instability of VNTR in M. tuberculosis as well. This finding is useful for inferring phylogenetics of M. tuberculosis based on the VNTR genotypes.

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Keywords : Tuberculosis, Beijing strains, IS6110-RFLP, VNTR, Evolution

This work was supported by the National Science and Technology Development Agency (NSTDA), Thailand.

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Vol 87 - N° 6

P. 498-501 - novembre 2007 Retour au numéro

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Evolution of some variable-number tandem repeat loci among a group of Beijing strains of Mycobacterium tuberculosis - 15/08/11

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