Activated STAT3 as a Correlate of Distant Metastasis in Prostate Cancer: A Secondary Analysis of Radiation Therapy Oncology Group 86-10 - 15/08/11
, Michelle DeSilvio b, Linda B. Mora a, Li Yan Khor c, Elizabeth Hammond d, Nazeel Ahmad a, Richard Jove a, Jeffrey Forman e, R. Jeffrey Lee f, Howard Sandler g, Alan Pollack c
Reprint requests: Javier F. Torres-Roca, M.D., Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612.Résumé |
Objective |
STAT3 participates in the regulation of cellular growth, survival, and oncogenesis. We evaluated the association between activated STAT3 expression and overall survival, disease-specific survival, distant metastasis, and local progression in a cohort of patients treated with either radiotherapy alone or radiotherapy plus short-term androgen blockade.
Methods |
A total of 456 assessable patients were included in the Radiation Therapy Oncology Group 86-10 trial. Of these, 62 patients had sufficient tissue for the analysis of STAT3 expression by immunohistochemistry. Nuclear staining was quantified by an image analysis system.
Results |
No significant difference was found in the distribution of clinical characteristics and assigned treatment between the patients available for STAT3 analysis (STAT3 cohort) and the others in the Radiation Therapy Oncology Group 86-10 trial (n = 394). Activated STAT3 correlated inversely with the development of distant metastasis (risk ratio [RR] = 0.81, P = 0.04) but not with overall survival, cause-specific survival, or local progression. Similar results were obtained when the data were dichotomized (ACIS index greater than 29%, RR = 0.41, P = 0.07). On multivariate analysis, activated STAT3 (continuous variable) was an independent predictor of distant metastasis (RR = 0.79, P = 0.04).
Conclusions |
Activated STAT3 was inversely related to the development of distant metastasis in prostate cancer. This marker should be evaluated further in a larger cohort of patients.
Le texte complet de cet article est disponible en PDF.Plan
| This study was supported by Radiation Therapy Oncology Group Pilot Seed grant RTOG-TRP-003, National Cancer Institute grant K08 CA 108926-01 to J. Torres-Roca, and a Pennsylvania Department of Health Grant. |
Vol 69 - N° 3
P. 505-509 - mars 2007 Retour au numéro
Article précédent
- Prevalence of Osteoporosis During Long-Term Androgen Deprivation Therapy in Patients with Prostate Cancer
- Juan Morote, Jacques Planas Morin, Anna Orsola, Jose M. Abascal, Carles Salvador, Enrique Trilla, Carles X. Raventos, Lluis Cecchini, Gloria Encabo, Jaume Reventos
- Significance of Neurovascular Bundle Formation Observed on Preoperative Magnetic Resonance Imaging Regarding Postoperative Erectile Function After Nerve-Sparing Radical Retropubic Prostatectomy
- Sang Eun Lee, Sung Kyu Hong, June Hyun Han, Byung Kyu Han, Ji Hyung Yu, Sung Jin Jeong, Seok-Soo Byun, Hak Jong Lee
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?