Cord blood allergen-specific IgE is associated with reduced IFN-γ production by cord blood cells: The Protection against Allergy—Study in Rural Environments (PASTURE) study - 15/08/11
, Serdar Sel, MD a, , Markus Johannes Ege, MD b, Gisela Büchele, MPH c, Nicole Blümer, PhD a, Susanne Krauss-Etschmann, MD b, d, Ileana Herzum, MD a, Christoph E. Albers a, Roger P. Lauener, MD e, Marjut Roponen, PhD f, Maija-Riitta Hirvonen, PhD f, Dominique A. Vuitton, MD g, Josef Riedler, MD h, Bert Brunekreef, PhD i, Jean-Charles Dalphin, MD, PhD j, Charlotte Braun-Fahrländer, MD k, Juha Pekkanen, MD f, l, Erika von Mutius, MD b, Harald Renz, MD a, ⁎ 
PASTURE Study Groupm
Reprint requests: Harald Renz, MD, Department of Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Giessen und Marburg GmbH, Baldingerstr.1, 35033 Marburg, Germany.Abstract |
Background |
It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants.
Objective |
To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences.
Methods |
As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-γ, IL-10, and TNF-⍺.
Results |
Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen’s egg, cow’s milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-γ production, but not with IL-5 and IL-10.
Conclusion |
Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-γ production.
Le texte complet de cet article est disponible en PDF.Key words : Prenatal, allergen specific IgE, cord blood, prospective birth cohort study, farming environment
Abbreviations used : aOR, CB, PASTURE
Plan
| Supported by the European Union (research grant QLK4-CT-2001-00250). |
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| Disclosure of potential conflict of interest: M. J. Ege receives grant support from the German Research Fund and the European Union. R. P. Lauener is a consultant for Phadia Inc and Nestlé Inc and receives grant support from the Swiss National Research Organization, the European Union, and the Kühne Foundation. D. A. Vuitton receives grant support from Agence Nationale Française de la recherche and Ministère Française de las Santé and has provided legal consultation or expert testimony on topics related to environmental health and biological and medical services. E. von Mutius has received grant support from the Deutsche Forschungsgemeinschaft, the European Commission, and the Bavarian Ministry for Research. The rest of the authors have declared that they have no conflict of interest. |
Vol 122 - N° 4
P. 711-716 - octobre 2008 Retour au numéro
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