Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms - 15/08/11
, Corinne Diefenbacher, MD a, Andrea Lehmann, MD a, Mascha Rochat, MD a, Joanne Brooks-Wildhaber, MPH b, Graham L. Hall, PhD c, Johannes H. Wildhaber, MD, PhD a
Reprint requests: Alexander Moeller, MD, Division of Respiratory Medicine, University Children’s Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.Abstract |
Background |
Respiratory symptoms are common in early childhood. The clinical characterization of disease presentation and hence its likely disease progression has so far been proven difficult.
Objective |
To investigate whether exhaled nitric oxide (NO) could be helpful to distinguish between subgroups of nonwheezy and wheezy young children less than 4 years of age.
Methods |
Exhaled NO was measured in 391 children (age 3-47 months) with nonwheezy and wheezy respiratory symptoms. Children were divided into 3 groups: children with recurrent cough but no history of wheeze (group 1), with early recurrent wheeze and a loose index for the prediction of asthma at school age (group 2), and with frequent recurrent wheeze and a stringent index for the prediction of asthma at school age (group 3).
Results |
Children from group 3 showed significantly higher median (interquartile range) fractional exhaled NO (FeNO) levels (11.7 [11.85]) than children from groups 1 (6.5 [5.5]; P < .001) and 2 (6.4 [6.5]; P < .001). No difference in FeNO levels was found between children from groups 1 and 2 (P = .91).
Conclusion |
Wheezy young children less than 4 years of age with a stringent index for the prediction of asthma at school age have elevated levels of FeNO compared with children with recurrent wheeze and a loose index for the prediction of asthma at school age or children with recurrent cough.
Le texte complet de cet article est disponible en PDF.Key words : Exhaled nitric oxide, early childhood asthma, infants, young children
Abbreviations used : AR, FeNO, ICS, NO
Plan
| Supported by an unrestricted grant by GlaxoSmithKline Switzerland. |
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| Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 121 - N° 3
P. 705-709 - mars 2008 Retour au numéro
Article précédent
- Rapid corticosteroid effect on β2-adrenergic airway and airway vascular reactivity in patients with mild asthma
- Eliana S. Mendes, Gabor Horvath, Michael Campos, Adam Wanner
- Does exhaled nitric oxide measurement help distinguish between wheezing phenotypes in preschool children?
- Leonard B. Bacharier
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