Radiographic vertebral morphology: A diagnostic tool in pediatric osteoporosis - 15/08/11
Reprint requests: Dr Etienne B. Sochett, The Hospital for Sick Children, Division of Endocrinology, 555 University Avenue, Toronto, ON M5G 1X8.Abstract |
Objective |
To assess the value of spinal radiographs in determining the significance of reductions in bone mass or density in chronically ill children.
Study design |
A pediatric scoring method for assessment of osteoporotic vertebral changes, developed on the basis of radiographs of 70 healthy controls and established adult scoring methods, was subsequently used to assess 32 pediatric patients with suspected secondary osteoporosis. Radiographic findings were correlated with bone mineral density (BMD), clinical data, and biochemistry.
Results |
Thirty-two patients (median age 14.1 years) were included. Assessment of spinal radiographs with the developed scoring method found previously undiagnosed spinal compression deformities in 11 patients (34%) of whom 9 were asymptomatic and 8 had lumbar spine (size-corrected) BMD measurements within ±2.0 SD of the age- and sex-specific norms. Fracture history and cumulative glucocorticoid (GC) dose did not differ between those with and without compression deformities.
Conclusions |
Vertebral compression fractures can be documented in a significant number of chronically ill children and are poorly predicted by single BMD measurements and clinical history. Assessment of vertebral morphology is recommended as an additional tool in the diagnostic workup of pediatric osteoporosis.
Le texte complet de cet article est disponible en PDF.Mots-clés : aBMD, BMAD, BMD, DXA, GC, S-25-OHD3, S-PTH
Plan
| Supported by the Foundation for Paediatric Research and the Helsingin Sanomat Centennial Foundation, Helsinki, Finland, and by a European Society for Paediatric Endocrinology Research Fellowship, sponsored by Novo Nordisk A/S (to O. Mäkitie); and by grants from the Canadian Institutes of Health Research and the Josie Walter Fund, Canada (to W. G. Cole). |
Vol 146 - N° 3
P. 395-401 - mars 2005 Retour au numéro
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