Long-term survival in severe combined immune deficiency: The role of persistent maternal engraftment - 15/08/11
Doi : 10.1016/j.jpeds.2004.09.010
Ilhan Tezcan, MD, PhD ⁎, Fugen Ersoy, MD, Ozden Sanal, MD, Tuba Turul, MD, Duygu Uckan, MD, Sevim Balci, MD, Gonul Hicsonmez, MD, M. Prieur, MD, S. Caillat-Zucmann, MD, Francois Le Deist, MD, Genevieve de Saint Basile, MD
From the Immunology Unit, the Hematology Unit, and the Medical Genetics Unit, Hacettepe University, Ihsan Dogramaci Children's Hospital, Sıhhiye, Ankara, Turkey; and the Histology, Embryology, and Cytogenetic Unit, the Clinical Immunology Unit, and INSERM U 429, Necker-Enfants Malades Hospital, Paris, France
Reprint requests: Dr Ilhan Tezcan, Hacettepe University Medical School, Ihsan Dogramaci Children's Hospital, Immunology Department, 06100, Sıhhiye, Ankara, Turkey.Abstract |
Two siblings with severe combıned immune defıcıency, one with maternal engraftment and detectable immunologic functions who was alive at the age of 8 years are presented. Both patients had the same JAK3 gene mutation, suggesting that maternal engraftment may result in immune competence leading to long-term survival in patients with severe combıned immune defıcıency.
Le texte complet de cet article est disponible en PDF.Mots-clés : GVHD, SCID
Plan
© 2005
Elsevier Inc. Tous droits réservés.
Vol 146 - N° 1
P. 137-140 - janvier 2005 Retour au numéro
Article précédent
- Pediatric hypereosinophilic syndrome (HES) differs from adult HES
- Hary T. Katz, S. Jaharul Haque, Fred H. Hsieh
- Proximal focal femoral deficiency—A rare entity in the sonographic differential diagnosis of developmental dysplasia of the hip
- Ralph Kayser, Konrad Mahlfeld, Henning Grasshoff, Harry Rudolph Merk
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?