A novel cause of invasive pulmonary infection in an immunocompetent patient: Aspergillus candidus - 15/08/11
, G.H. Arriagada b, J.E.C. Martins b, T.Y. Takagaki a
Corresponding author. Address: Av. Dr Enéas de Carvalho Aguiar, 255, Sala 7079, CEP 05403-900 São Paulo, SP, Brazil. Tel.: +55 11 30697202; fax: +55 11 30645374.Abstract |
Aspergillus candidus, a common contaminant of grain dust, may represent an important respiratory hazard to grain workers, considering its immunomodulating capability by producing p-terphenyl metabolites and terprenins, potent cytotoxic substances. However, there are only three cases of A. candidus infection in the English literature, one fatal solitary brain mass and two onychomycosis. We describe the first case of invasive pulmonary infection and skin abscesses due to A. candidus, determination of minimal inhibitory concentration for anti-fungals, and the successful treatment with liposomal amphotericin B and itraconazole. Possible mechanisms involved in the dissemination of infection in an immunocompetent host are discussed.
Le texte complet de cet article est disponible en PDF.Keywords : Aspergillus candidus, Invasive aspergillosis, p-terphenyl, Review, Terprenins
Plan
Vol 51 - N° 4
P. e195-e197 - novembre 2005 Retour au numéro
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