Functional Role of Eosinophils in Gastrointestinal Inflammation - 12/08/11

Doi : 10.1016/j.iac.2008.10.004

Simon P. Hogan, PhD
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA

Abstract

Eosinophilic gastrointestinal (GI) diseases (EGIDs) are characterized by a rich eosinophilic inflammation of the GI tract. Clinical and experimental studies suggest that eosinophils have a pathogenic role in EGIDs; however, the function of eosinophils in these diseases remains an enigma. This article describes eosinophil immunoregulatory and effector function and discusses the possible involvement of these pathways in EGIDs.

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Keywords : Eosinophil, Esophagitis, Eosinophilic gastroenteritis, Inflammatory bowel disease

Plan

Eosinophil-derived cytokines

Eosinophil-derived granule cationic proteins

Eosinophil degranulation

Eosinophilic gastrointestinal disorders

Esophageal Disorders

Small Bowel Disorders

Colonic Disorders

Summary

This work was supported in part by the Crohn’s and Colitis Foundation of America.

This review article was largely adapted from other references previously published.^{1Rothenberg M.E., Mishra A., Brandt E.B., et al. Gastrointestinal eosinophils in health and disease Adv Immunol 2001 ; 78 : 291-328 [cross-ref]

Cliquez ici pour aller à la section Références, 2Hogan S.P., Rothenberg M.E., Forbes E., et al. Chemokines in eosinophil-associated gastrointestinal disorders Curr Allergy Asthma Rep 2004 ; 4 (1) : 74-82 [cross-ref]

Cliquez ici pour aller à la section Références, 3Rothenberg M.E. Eosinophilic gastrointestinal disorders (EGID) J Allergy Clin Immunol 2004 ; 113 (1) : 11-28 [cross-ref]

Cliquez ici pour aller à la section Références, 4Hogan S.P., Foster P.S., Rothenberg M.E. Experimental analysis of eosinophil-associated gastrointestinal diseases Curr Opin Allergy Clin Immunol 2002 ; 2 : 239-248 [cross-ref]

Cliquez ici pour aller à la section Références, 5Rothenberg M.E., Mishra A., Brandt E.B., et al. Gastrointestinal eosinophils Immunol Rev 2001 ; 179 : 139-155

Cliquez ici pour aller à la section Références}