Effect of Acute Myocardial Infarction on Erythrocytic Glutathione Peroxidase 1 Activity and Plasma Vitamin E Levels - 12/08/11
Résumé |
Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 ± 9.2 vs 47.3 ± 16.6 U/g hemoglobin; p <0.001). There was a significant inverse correlation between GPX-1 activity and acute myocardial infarction incidence (p = 0.032). In addition, plasma vitamin E inversely correlated with acute myocardial infarction incidence (p = 0.017). The incidence of acute myocardial infarction increased only in patients with low plasma vitamin E and low erythrocytic GPX-1 activity, but not in those with high vitamin E and low GPX-1 activity, low vitamin E and high GPX-1 activity, or high vitamin E and high GPX-1 activity. In conclusion, acute myocardial infarction incidence significantly increased in patients with a concomitant decrease in plasma vitamin E and erythrocytic GPX-1 activity, suggesting that both GPX-1 and vitamin E may be valuable markers for monitoring cardiovascular events, particularly when used in combination.
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This work was supported by Grants CMRPD160312 and CMRPD160231 from Chang Gung University, Taoyuan, Taiwan; NSC97-2320-B-182-015-MY3, NSC96-2320-B-182A-003-MY3, and NSC96-2320-B-182-015-MY3 from the National Science Council of Taiwan, Taipei, Taiwan; and EMRPD160241 from the Ministry of Education of Taiwan, Taipei. |
Vol 103 - N° 4
P. 471-475 - février 2009 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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