Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix - 12/08/11
Résumé |
Objective |
Identify overlap of the transcriptome of myometrium and cervix in association with human labor.
Study Design |
The transcriptional profile of myometrial and cervical biopsies obtained from women in spontaneous labor at term (n = 9) and not in labor (n = 9) were characterized by Affymetrix v2 U133 plus 2 arrays. Common canonical pathways and functional groups were identified by Ingenuity Pathway Analysis.
Results |
One hundred ten genes (false discovery rate < 1%) were commonly up-regulated by myometrium and cervix in association with labor and 29 genes (false discovery rate < 1%) down-regulated. Fold change in expression of up-regulated genes was strongly correlated; myometrium vs cervix (r = 0.51; P < .001), with no relationship in down-regulated genes (r = 0.26; P = .16). Canonical pathway analysis established up-regulation of inflammatory pathway signaling, with greatest increases in cellular movement and immune response gene ontology groups.
Conclusion |
Gestational tissues exhibit a core inflammatory response in association with human parturition, with pathways regulating cellular trafficking dominating.
Le texte complet de cet article est disponible en PDF.Key words : gene array, inflammation, parturition
Plan
| Support provided by the Chief Scientist Office, Scotland, and WellBeing of Women, London, UK. |
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| Cite this article as: Bollopragada S, Youssef R, Jordan F, et al. Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix. Am J Obstet Gynecol 2009;200:104.e1-104.e11. |
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| Reprints not available from the authors. |
Vol 200 - N° 1
P. 104.e1-104.e11 - janvier 2009 Retour au numéro
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