Oral findings in 58 adults with tuberous sclerosis complex - 12/08/11
Reprint requests: Thomas N. Darling, MD, PhD, Department of Dermatology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814.Washington, DC and Bethesda, Maryland
Abstract |
Background |
Gingival fibromas and dental pitting are among the diagnostic criteria for tuberous sclerosis complex (TSC).
Objective |
Our goal was to document the oral findings in 58 adult patients with TSC.
Results |
Forty patients (69%) had oral fibromas, appearing mostly on the attached or interdental gingiva. Other oral mucosal sites with fibromas included buccal and labial mucosa, the superior labial frenulum, palate, and tongue. In all, 56 patients (97%) had multiple dental enamel pits.
Limitations |
This case series comprised predominantly adult women with TSC and lymphangioleiomyomatosis.
Conclusions |
Oral fibromas in TSC are mostly, but not exclusively, gingival. Dental pits are present in nearly all patients. The multiple oral papules in TSC may appear similar to those observed in Cowden syndrome, Birt-Hogg-Dubé syndrome, and rarely in multiple endocrine neoplasia type 1.
Le texte complet de cet article est disponible en PDF.Abbreviations used : LAM, TSC
Plan
| Supported by the Clinical Scientist Development Award from the Doris Duke Charitable Foundation, R01 CA100907, and the Intramural Research Program of the National Institutes of Health, National Heart, Lung, and Blood Institute. Conflicts of interest: None declared. Disclaimer: The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, or the Department of Defense. |
Vol 56 - N° 5
P. 786-790 - mai 2007 Retour au numéro
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