Psychoneuroimmune Implications of Type 2 Diabetes: Redux - 12/08/11
Corresponding author.Résumé |
A sizable body of knowledge has arisen demonstrating that type 2 diabetes (T2D) is associated with alterations in the innate immune system. The resulting proinflammatory-leaning imbalance is implicated in the development of secondary disease complications and comorbidities, such as delayed wound healing, accelerated progress of atherosclerosis, and retinopathy, in people who have T2D. New experimental data and the results of recently published health-related quality-of-life surveys indicate that individuals who have T2D experience diminished feelings of happiness, well being, and satisfaction with life. These emotional and psychological consequences of T2D point to altered neuroimmunity as a previously unappreciated complication of T2D. This article discusses recent data detailing the impact of T2D on a person’s PNI response.
Le texte complet de cet article est disponible en PDF.Keywords : Cytokine, Fever, Inflammation, Insulin resistance, Macrophage, Mental health, Obesity, Sickness behavior
Plan
| This article is a version of an article previously published in Neurologic Clinics: Roth J, Rummel C, Barth SW, Gerstberger R, Hubschle T. Molecular aspects of fever and hyperthermia. Neurol Clin 2006;24(3):421–39.This research was supported by grants from the National Institutes of Health (DK64862 and NS58525, to G.G.F.) and University of Illinois Agricultural Experiment Station (to G.G.F). |
Vol 29 - N° 2
P. 339-358 - mai 2009 Retour au numéro
Article précédent
- Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences
- Jonathan P. Godbout, Rodney W. Johnson
- Psychoneuroimmunology of Stroke
- Robert Skinner, Rachel Georgiou, Peter Thornton, Nancy Rothwell
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?