The presence of a diastema or diastemata between teeth is a common feature found in the anterior dentition. Many forms of therapy can be used for diastema closure. A carefully developed diagnosis and advanced planning allows the most appropriate treatment to be determined for each individual case to address the patient's needs. Clinical considerations, advantages, disadvantages, and alternative treatment modalities for diastema closure are discussed in this article and a clinical case is presented to illustrate the application of these techniques.