Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure - 11/08/11
, Ileana L. Piña, MD d, Jalal K. Ghali, MD e, Lynne E. Wagoner, MD f, Stephanie H. Dunlap, DO g, Todd A. Schwartz, Dr PH c, Wendy Gattis Stough, PharmD h, Mandeep R. Mehra, MBBS i, Gary Michael Felker, MD, MHS j, Jun R. Chiong, MD, MPH k, James Herbert Patterson, PharmD b, John Kim, PharmD l, Javed Butler, MD, MPH m, Ron M. Oren, MD nRésumé |
Background |
Reduced hemoglobin has been associated with adverse outcomes in heart failure, but the relationship of hemoglobin to health-related quality of life in outpatients with this syndrome has not been well studied.
Methods |
We used data from the prospective, observational Study of Anemia in a Heart Failure Population Registry, which randomly selected outpatients with heart failure from specialty or community cardiology clinics. Hemoglobin was determined by finger stick at baseline and during medically indicated follow-up visits. Health-related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire and the Minnesota Living with Heart Failure Questionnaire at 3-month intervals for 12 months.
Results |
Adjusted regression analysis demonstrated a significant, direct, linear relationship between hemoglobin and health-related quality of life from baseline through 12 months follow-up on all Kansas City Cardiomyopathy Questionnaire domains (all P < .001) and the Summary and Physical domains of the Minnesota Living with Heart Failure Questionnaire (all P < .05). Adjusted categorical analysis of the change in Kansas City Cardiomyopathy Questionnaire Clinical scores associated with change in hemoglobin from baseline to 6 months also showed a significant relationship between increasing hemoglobin and improved health status (5.9 ± 1.8 units for a hemoglobin increase of ≥1 g/dL, 0.7 ± 1.2 units for change in hemoglobin <1 g/dL, and −2.6 ± 1.4 units for a ≥1 g/dL decrease in hemoglobin, P < .001).
Conclusions |
These prospective, observational results indicate that reduced hemoglobin is associated with poorer quality of life in patients with heart failure. Additional studies will be required to establish if this is a cause-and-effect relationship.
Le texte complet de cet article est disponible en PDF.Plan
Vol 158 - N° 6
P. 965-971 - décembre 2009 Retour au numéro
Article précédent
- Cardiac resynchronization therapy utilization for heart failure: Findings from IMPROVE HF
- Anne B. Curtis, Clyde W. Yancy, Nancy M. Albert, Wendy Gattis Stough, Mihai Gheorghiade, J. Thomas Heywood, Mark L. McBride, Mandeep R. Mehra, Christopher M. OConnor, Dwight Reynolds, Mary Norine Walsh, Gregg C. Fonarow
- The impact of kidney transplantation on heart failure risk varies with candidate body mass index
- Krista L. Lentine, Huiling Xiao, Daniel C. Brennan, Mark A. Schnitzler, Todd C. Villines, Kevin C. Abbott, David Axelrod, Jon J. Snyder, Paul J. Hauptman
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?