Pathogenesis of Epidermolysis Bullosa Acquisita - 11/08/11
, Detlef Zillikens, MD
Corresponding author.Résumé |
Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering skin disease characterized by autoantibodies to type VII collagen. Clinically, a noninflammatory and an inflammatory variant of EBA can be distinguished. Despite major achievements in the understanding of EBA, current therapeutic options are far from optimal. However, with an emerging and more detailed understanding of the events ultimately leading to blister formation in EBA, novel therapeutic options may become available for patients with EBA. Therefore, this article reviews the current understanding of the pathogenesis of EBA and may indicate possible avenues towards a more targeted therapy for EBA and possibly other antibody-mediated autoimmune diseases.
Le texte complet de cet article est disponible en PDF.Keywords : Skin, Epidermolysis bullosa acquisita, Autoimmunity, Blister, Animal model
Plan
| Grant support: DFG Excellence Cluster “Inflammation at Interfaces” (DFG EXC 306/1), DFG LU877/5-1, Focus Program “Autoimmunity” of the University of Lübeck. |
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| Financial disclosures and/or conflict of interest: The authors have nothing to disclose. |
Vol 29 - N° 3
P. 493-501 - juillet 2011 Retour au numéro
Article précédent
- Diagnosis and Clinical Features of Epidermolysis Bullosa Acquisita
- Frédéric Caux
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- Maryia Miteva, Dédée F. Murrell, Antonella Tosti
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