A Globally Available Internet-Based Patient Survey of Pemphigus Vulgaris: Epidemiology and Disease Characteristics - 11/08/11

Doi : 10.1016/j.det.2011.03.016

Vibha K. Gupta, BS ^a, Theodore E. Kelbel, BS ^a, Daniela Nguyen, MS ^b, Katherine C. Melonakos, BS ^a, Dédée F. Murrell, MA, BMBCh, FAAD, MD, FACD ^c, Yan Xie, MS ^d, Andrew Mullard, MS ^e, Philip L. Reed, MSc, PhD ^e, Kristina Seiffert-Sinha, MD ^a,^f, Animesh A. Sinha, MD, PhD ^a,^f,^⁎
^a Division of Dermatology and Cutaneous Sciences, Center for Investigative Dermatology, Michigan State University, 4179 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA
^b Department of Dermatology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
^c Department of Dermatology, St George Hospital, University of New South Wales, Gray Street, Kogarah, Sydney, NSW 2217, Australia
^d Center for Statistical Training and Consulting, 152 Giltner Hall, Michigan State University, East Lansing, MI 48824, USA
^e Biomedical Research & Informatics Core, Department of Epidemiology, 100 Conrad Hall, Michigan State University, East Lansing, MI 48824, USA
^f Department of Dermatology, State University of New York at Buffalo and Roswell Park Cancer Center, Buffalo, NY 14263, USA

Corresponding author. Department of Dermatology, State University of New York at Buffalo and Roswell Park Cancer Center, MRC 234, Buffalo, NY 14263.

Résumé

The authors developed an anonymous, Web-based survey instrument available globally, and collected data from 171 pemphigus vulgaris (PV) patients to assemble epidemiologic data pertaining to an extensive set of clinical parameters in demographically diverse populations. The results showed female predominance, prevalent onset of disease in the fifth decade of life, and a strong correlation of PV with thyroid disease and type 1 diabetes in patients and family members. Most patients have a history of either mucosal-only or mucocutaneous lesions, but numerous patients self-report cutaneous lesions only, without previous or concurrent mucosal lesions, especially in the non–North American PV population.

Le texte complet de cet article est disponible en PDF.

Keywords : Pemphigus vulgaris, Epidemiology, Online survey, Autoimmune disease comorbidity and family history, Trigger factors