IgE, mast cells, basophils, and eosinophils - 11/08/11

Doi : 10.1016/j.jaci.2009.11.017

Kelly D. Stone, MD, PhD, Calman Prussin, MD, Dean D. Metcalfe, MD ^⁎
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md

Reprint requests: Dean Metcalfe, MD, National Institutes of Health, National Institute of Allergy and Infectious Diseases, 10 Center Dr, Bldg 10, Rm 11C205, MSC 1881, Bethesda, MD 20892-1881.

Abstract

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcεRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.

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Key words : IgE, mast cells, basophils, allergy, mastocytosis, hypereosinophilic syndromes

Abbreviations used : AID, CD40L, CEL, CysLT, ECP, EDN, EPO, ITAM, LT, MBP, PAF, PG, SCF, SM, STAT6, TLR

Plan

	Supported by the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases.
	Disclosure of potential conflict of interest: K. D. Stone is an employee of the National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Intramural Research. C. Prussin and D. D. Metcalfe are employees of the National Institutes of Health, Department of Health and Human Services.