Innate immunity - 11/08/11
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Abstract |
Recent years have witnessed an explosion of interest in the innate immune system. Questions about how the innate immune system senses infection and empowers a protective immune response are being answered at the molecular level. These basic science discoveries are being translated into a more complete understanding of the central role innate immunity plays in the pathogenesis of many human infectious and inflammatory diseases. It is particularly exciting that we are already seeing a return on these scientific investments with the emergence of novel therapies to harness the power of the innate immune system. In this review we explore the defining characteristics of the innate immune system, and through more detailed examples, we highlight recent breakthroughs that have advanced our understanding of the role of innate immunity in human health and disease.
Le texte complet de cet article est disponible en PDF.Key words : Host defense, innate immunity, Toll-like receptors, nucleotide oligomerization domain–like receptors
Abbreviations used : DAMP, IPAF, IRAK4, MAL, MPL, MyD88, NK, NLR, NLRP3, NOD, SNP, TIR, TIRAP, TLR
Plan
S. E. T. is supported by a Chaim Roifman Scholar Award from the Canadian Immunodeficiency Society and a Career Development Award from the Canadian Child Health Clinician Scientist Program (CCHCSP)-a CIHR Strategic Training Program and operating grants from the Canadian Cystic Fibrosis Foundation and the CIHR Team in Mutagenesis and Infectious Diseases. D.H.B. is supported by NIH grants AI 038425, AI072115 and AI070535. |
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Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest. |
Vol 125 - N° 2S2
P. S24-S32 - février 2010 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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