Drug allergy - 11/08/11
Reprint requests: David A. Khan, MD, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8859.Abstract |
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including β-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.
Le texte complet de cet article est disponible en PDF.Key words : Drug allergy, adverse drug reactions, drug hypersensitivity, graded challenge, desensitization, tolerance, penicillin, cephalosporin, carbapenem, sulfonamide, local anesthetic, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drug, biologic modifiers
Abbreviations used : ACE-I, ADR, AERD, ASA, DILE, DRESS, NSAID, NSF, PPL, RCM, SJS, TEN, TMP-SMX
Plan
| Disclosure of potential conflict of interest: D. A. Khan is a speaker for AstraZeneca and Merck. R. Solensky is speaker for Sepracor, AstraZeneca, and GlaxoSmithKline and has served as an expert witness on the topic of drug allergies. |
Vol 125 - N° 2S2
P. S126-S137.e1 - février 2010 Retour au numéro
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