Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru - 11/08/11
Reprint requests: William Checkley, MD, PhD, Johns Hopkins University, Division of Pulmonary and Critical Care, 1830 Monument St, Fifth Floor, Baltimore, MD 21205.Abstract |
Background |
Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes.
Objective |
We sought to determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a periurban shantytown in Lima, Peru.
Methods |
We enrolled 725 adolescents aged 13 to 15 years who were administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing, and exhaled nitric oxide (eNO). We calculated distances from the main avenue for all households and measured indoor particulate matter in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO levels, and FEV1/forced vital capacity ratio as a function of distance.
Results |
Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (P < .05). The odds of atopy increased by a factor of 1.07 for every 100-meter difference in the distance from the avenue (P = .03). We found an inverse relationship in prebronchodilator FEV1/forced vital capacity and distance to the avenue in female subjects (P = .01) but not in male subjects. We did not find an association between eNO or household particulate matter levels and distance.
Conclusion |
Living in close proximity to a high-traffic-density avenue in a periurban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile-source pollutants in periurban areas of developing countries might help reduce the burden of asthma symptoms and atopy.
Le texte complet de cet article est disponible en PDF.Key words : Asthma symptoms, atopy, distance, traffic, particulate matter, spirometry
Abbreviations used : BMI, eNO, FVC, ISAAC, NO2, PM, PM2.5, PM10
Plan
| Supported by a Johns Hopkins Center for Global Health Award (PI: Hansel) and the Fogarty International Center Training Grant (Grant R24 TW007988). W.C. was supported by a Clinician Scientist Award from the Johns Hopkins University, a K99/R00 Pathway to Independence Award (K99HL096955) from the National Heart, Lung, and Blood Institute, National Institutes of Health, and by a contract (HHSN268200900033C) with the National Heart, Lung, and Blood Institute, National Institutes of Health. K.B. was supported in part by the Mary Beryl Patch Turnbull Scholar Program. C.L.R. was a Fogarty International Clinical Research Scholar during the time of this work and was further supported by Tufts University School of Medicine. L.M.B. was supported by a predoctoral NIH T35 Training Grant (T35AI065385). Support for exposure measurements were provided by National Institute for Environmental Health Sciences grants ES015903 and ES03819. Additional support came from A.B. PRISMA and collaborators at JHU. Lincoln Diagnostics (Decatur, Ill) and ALK-Abelló (Round Rock, Tex) generously donated all skin prick atopy kits and antigens, respectively, used in this in this study. Aerocrine (New Providence, NJ) provided us, at discount, materials for eNO testing. |
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| Disclosure of potential conflict of interest: K. Barnes has received research support from the National Institutes of Health and Sanofi-Aventis. The rest of the authors have declared that they have no conflict of interest. |
Vol 127 - N° 4
P. 875-882 - avril 2011 Retour au numéro
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