Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis - 10/08/11
, Johanna Wohlgensinger, PhD a, Remo Frei, PhD a, Sondhja Bitter, MD b, c, Christian Bieli, MD, PhD a, Susanne Loeliger a, Gisela Büchele, MPH e, Josef Riedler, MD f, Jean-Charles Dalphin, MD, PhD g, Sami Remes, MD h, Marjut Roponen, PhD i, Juha Pekkanen, MD i, Michael Kabesch, MD j, Bianca Schaub, MD k, Erika von Mutius, MD, MSc k, Charlotte Braun-Fahrländer, MD b, c, Roger Lauener, MD a, dPASTURE Study Group
Reprint requests: Caroline Roduit, MD, MPH, Kinderspital Zurich, Steinwiesstrasse 75, 8032 Zurich, Switzerland.Abstract |
Background |
Cross-sectional studies have suggested that prenatal farm exposures might protect against allergic disease and increase the expression of receptors of the innate immune system. However, epidemiologic evidence supporting the association with atopic dermatitis remains inconsistent.
Objective |
To study the association between prenatal farm-related exposures and atopic dermatitis in a prospective study. We further analyzed the association between the expression of innate immune genes at birth and atopic dermatitis.
Methods |
A total of 1063 children who participated in a birth cohort study, Protection against Allergy-Study in Rural Environments, were included in this study. Doctor diagnosis of atopic dermatitis was reported by the parents from 1 to 2 years of age by questionnaire. Gene expression of Toll-like receptors (TLRs) and CD14 was assessed in cord blood leukocytes by quantitative PCR.
Results |
Maternal contact with farm animals and cats during pregnancy had a significantly protective effect on atopic dermatitis in the first 2 years of life. The risk of atopic dermatitis was reduced by more than half among children with mothers having contact with 3 or more farm animal species during pregnancy compared with children with mothers without contact (adjusted odds ratio, 0.43; 95% CI, 0.19-0.97). Elevated expression of TLR5 and TLR9 in cord blood was associated with decreased doctor diagnosis of atopic dermatitis. A significant interaction between polymorphism in TLR2 and prenatal cat exposure was observed in atopic dermatitis.
Conclusion |
Maternal contact with farm animals and cats during pregnancy has a protective effect on the development of atopic dermatitis in early life, which is associated with a lower expression of innate immune receptors at birth.
Le texte complet de cet article est disponible en PDF.Key words : Prenatal, farm animal, Toll-like receptors, atopic dermatitis, gene-environment interaction
Abbreviations used : EFRAIM, GEE, GMR, ISAAC, OR, PASTURE, SNP, TLR
Plan
| Supported by European Union research grants PASTURE/EFRAIM (QRLT4-CT 2001-00250, KBBE-2-2-06) and the Kühne-Foundation. |
|
| Disclosure of potential conflict of interest: J. Pekkanen has received research support from the European Union, Academy of Finland, TEKES, Farmers’ Social Insurance Institution, EVO, and the Juho Vainio Foundation. M. Kabesch has received reimbursement for speaker activities from Roxall, Glaxo Wellcome, Novartis, and Allergopharma; has served on the scientific advisory board for Sanofi Aventis; and has received research support from Deutsche Forschungsgemeinschaft, Bundesministerium fur Bildung und Forschung, and the European Union. E. von Mutius has served as a consultant for GSK, UCB, Protectimmune, and Novartis and has received research support from Airsonett AB. R. Lauener has received research support from the European Union and the Kuhne Foundation. The rest of the authors have declared that they have no conflict of interest. |
|
| The PASTURE Study Group: Gertraud Weiß, Ellen Üblagger, Claudia Humer, Manuela Rußegger (Austria); Raija Juntunen, Reetta Tiihonen, Pekka Tiittanen, Kati Huttunen, Suvi Virtanen, Timo Kauppila, Aino Nevalainen, Tomi-Pekka Tuomainen, Anne Karvonen, Mikko Lappalainen (Finland); Marie-Laure Dalphin, Dominique Vuitton, Renaud Piarroux, Gabriel Reboux, Sandrine Roussel, Bertrand Sudre (France); Susanne Schmid, Sabina Illi, Nicola Korherr, Jon Genuneit, Richard Peter, Serdar Sel, Nicole Blümer, Petra Pfefferle, Harald Renz (Germany); Bert Brunekreef, Ulrike Gehring, Gert Dockes (The Netherlands); Felix H. Sennhauser (Switzerland). |
Vol 127 - N° 1
P. 179 - janvier 2011 Retour au numéro
Article précédent
- Nasal AMP and histamine challenge within and outside the pollen season in patients with seasonal allergic rhinitis
- Sriram Vaidyanathan, Peter Williamson, Karine Clearie, Ashley Morrison, Brian Lipworth
- Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization
- Carolyn J. Broccardo, Spencer Mahaffey, John Schwarz, Lisa Wruck, Gloria David, Patrick M. Schlievert, Nichole A. Reisdorph, Donald Y.M. Leung
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?