Papular epidermal nevus with “skyline” basal cell layer (PENS) - 10/08/11
, Isabel Colmenero, MD b, Leonard Kristal, MD c, Lourdes Navarro, MD a, Christian Hafner, MD d, Angela Hernández-Martín, MD a, Luis Requena, MD e, Rudolf Happle, MD f
Reprint requests: Antonio Torrelo, MD, Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009-Madrid, Spain.Abstract |
Background |
Several types of epidermal keratinocytic nevus are recognized.
Objective |
We sought to describe a previously unreported keratinocytic nevus with distinctive clinical and histopathologic features in 5 patients.
Methods |
We performed a clinical and photographic review, and obtained skin biopsy samples for histopathologic examination from each patient. Genetic analysis to screen for fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha hotspot mutations was performed on lesional skin from two patients.
Results |
Five infants (2 male, 3 female) had from 1 to 11 lesions present since birth. These consisted of 1- to 7-mm hyperkeratotic papules with a rough, flat surface and a round, commalike, rectangular, or polygonal shape. Histopathologic examination showed acanthosis with broad and rectangular rete ridges, and strikingly arranged basal cells with palisaded nuclei. Genetic testing on paraffin-embedded specimens from two patients ruled out hotspot mutations in the fibroblast growth factor receptor 3 and phosphatidylinositol 3-kinase, catalytic, alpha genes.
Limitations |
A small number of patients are presented.
Conclusion |
We propose the name “papular epidermal nevus with ‘skyline’ basal cell layer” (PENS) for this newly recognized condition.
Le texte complet de cet article est disponible en PDF.Key words : congenital nevus, epidermal nevus, keratinocytic nevus, nevus, newborn, skin hamartoma
Abbreviations used : FGFR3, PENS, PIK3CA
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 64 - N° 5
P. 888-892 - mai 2011 Retour au numéro
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