Update on morphea : Part II. Outcome measures and treatment - 10/08/11
Abstract |
Morphea is a rare fibrosing disorder of the skin and underlying tissues. The underlying pathogenesis of morphea is not completely understood at this time, but ultimately results in an imbalance of collagen production and destruction. Evidence-based treatment options of morphea are limited secondary to the rarity of the disease, and the lack of universally used validated outcome measures. The most commonly used outcome measures are skin scores, computerized surface area measurement, durometer, cutometer, thermography, and ultrasound measurements. The Localized Scleroderma Cutaneous Assessment Tool is a promising recently validated skin scoring tool that allows differentiation between activity and damage, is sensitive to change, and requires no additional equipment. The most robust data in the treatment of morphea exists for methotrexate in combination with systemic steroids and ultraviolet A1.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune connective tissue disorder, fibrosing disorders, localized scleroderma, morphea, scleroderma, systemic sclerosis
Plan
Supported in part by a Merit Review Grant from the Department of Veterans Affairs Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development, and by the National Institutes of Health (grant NIH K24-AR 02207) to Dr Werth. |
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This article does not reflect the views of the VHA or the US Government. |
Vol 64 - N° 2
P. 231-242 - février 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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