Update on morphea : Part I. Epidemiology, clinical presentation, and pathogenesis - 10/08/11
Abstract |
Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody serologies. However, involvement of morphea is almost uniformly limited to those tissues derived from the mesoderm. The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune connective tissue disorder, fibrosing disorders, localized scleroderma, morphea, scleroderma, systemic sclerosis
Plan
Supported in part by a Merit Review Grant from the Department of Veterans Affairs Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development, and by the National Institutes of Health (grant NIH K24-AR 02207) to Dr Werth. |
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This article does not reflect the views of the VHA or the US Government. |
Vol 64 - N° 2
P. 217-228 - février 2011 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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