Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia - 10/08/11
Doi : 10.1016/j.jpeds.2006.06.037
Monica L. Hulbert, MD, Douglas J. Scothorn, MD, PhD, Julie A. Panepinto, MD, MSPH, J. Paul Scott, MD, George R. Buchanan, MD, Sharada Sarnaik, MD, Robert Fallon, MD, PhD, Jen-Yih Chu, MD, Winfred Wang, MD, James F. Casella, MD, Linda Resar, MD, Brian Berman, MD, Thomas Adamkiewicz, MD, Lewis L. Hsu, MD, PhD, Kimberly Smith-Whitley, MD, Donald Mahoney, MD, Gerald Woods, MD, Masayo Watanabe, MD, Michael R. DeBaun, MD, MPH ⁎ 
Washington University School of Medicine, St. Louis, MO; The University of Texas Southwestern Medical Center, Dallas, TX; Medical College of Wisconsin, Milwaukee, WI; Children’s Hospital of Michigan, Detroit, MI; Cardinal Glennon Children’s Hospital, St. Louis, MO; St. Jude Children’s Research Hospital, Memphis, TN; Johns Hopkins University School of Medicine, Baltimore, MD; Rainbow Babies & Children’s Hospital, Cleveland, OH; Emory University School of Medicine, Atlanta, GA; Children’s Hospital of Philadelphia, Philadelphia, PA; Baylor College of Medicine, Houston, TX; and University of Missouri–Kansas City, Kansas City, MO.
Reprint requests: Michael R. DeBaun, MD, MPH, Washington University School of Medicine, 4444 Forest Park Blvd, CB 8519, St. Louis, MO 63108.Résumé |
A retrospective cohort study of children with sickle cell anemia (SCA) and strokes was used to test the hypothesis that exchange transfusion at the time of stroke presentation more effectively prevents second strokes than does simple transfusion. Children receiving simple transfusion had a 5-fold greater relative risk (95% confidence interval = 1.3 to 18.6) of second stroke than those receiving exchange transfusion.
Le texte complet de cet article est disponible en PDF.Abbreviations : CI, RR, SCA, SCD
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Vol 149 - N° 5
P. 710-712 - novembre 2006 Retour au numéro
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