Protective Effects of the Alcohol Dehydrogenase-ADH1B Allele in Children Exposed to Alcohol During Pregnancy - 10/08/11
, Lucinda G. Carr, PhD, Julie Croxford, BSc, Robert J. Sokol, MD, Ting-Kai Li, MD, Joseph L. Jacobson, PhD
Reprint requests: Sandra W. Jacobson, PhD, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2751 E. Jefferson, Room 460, Detroit, MI 48207.See editorial, p 5.
Abstract |
Objectives |
To examine alcohol use for mothers with and without an ADH1B3 allele and the moderating effects of the maternal and child ADH1B3 allele on a broad range of infant and 7.5-year outcomes.
Study design |
Blood samples from 263 black mother/child pairs (217 mothers and 239 children) were analyzed to determine incidence of the ADH1B allele and the relation of the maternal allele to pregnancy drinking assessed at every prenatal clinic visit. Moderating effects of ADH1B were examined by dichotomizing the moderator variable and performing regression analyses on the 2 groups.
Results |
Pregnancy drinking at conception was less frequent in the presence of the ADH1B3 allele, and virtually no adverse effects were found in children whose mothers had at least one ADH1B3 allele. By contrast to the maternal allele, we found no consistent pattern of greater vulnerability in children lacking the ADH1B3 allele.
Conclusions |
These data are consistent with the hypothesis that the maternal ADH1B3 allele provides some protection to the fetus from prenatal alcohol exposure.
Mots-clés : AA, BAC, CPT, FAS, FASD, FD, FTII, MAST, MDI, RT, TRF, VExP, WISC-III
Plan
| Supported by grants RO1-AA06966, R01-AA09524, and P50-AA07606 from the National Institute on Alcohol Abuse and Alcoholism, with supplemental support from a Minority Biomedical Research Support grant SO6-RR08167 from the National Institutes of Health, and a grant from the Joseph Young, Sr., Fund from the State of Michigan. |
Vol 148 - N° 1
P. 30-37 - janvier 2006 Retour au numéro
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