Early response to vitamin D2 in children with calcium deficiency rickets - 09/08/11
, Christian O. Isichei, BM, BCh, MS, John M. Pettifor, MB, BCh, PhD
Reprint requests: Dr Philip R. Fischer, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905.Résumé |
Objective |
To assess the effect of vitamin D2 administration on serum vitamin D metabolite concentrations in calcium deficiency rickets.
Study design |
We administered vitamin D2, 50,000 IU orally to 16 Nigerian children 15 to 48 months of age with radiographically active rickets. We measured calcium and vitamin D metabolites at baseline and at 1, 3, 7, and 14 days.
Results |
At baseline, ranges of serum 25-hydroxyvitamin D (25(OH)D) concentrations were 18 to 40 nmol/L (7-16 ng/mL), and 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentrations were 290 to 790 pmol/L (120-330 pg/mL). After vitamin D administration, serum 25(OH)D and 1,25(OH)2D concentrations rapidly rose and peaked at 2.8 and 1.9 times the baseline values (P < .001), respectively, at 3 days. Positive correlations between 1,25(OH)2D and 25(OH)D were strongest at day 3 (r = 0.84, P < .001) and weakest at day 14 (r = 0.41, P = .11). The relationship of 1,25(OH)2D with 25(OH)D at baseline and the increase in 1,25(OH)2D in response to vitamin D were similar to those described in children with vitamin D deficiency. However, unlike the pattern in vitamin D deficiency, 1,25(OH)2D remained positively correlated with 25(OH)D after administration of vitamin D.
Conclusion |
Dietary calcium deficiency increases the demand for 25(OH)D above that required in vitamin D deficiency to optimize 1,25(OH)2D concentrations. Assessment of vitamin D sufficiency in persons or communities may need to be adjusted for habitual dietary calcium intake.
Le texte complet de cet article est disponible en PDF.Abbreviations : 1,25-(OH)2D, 25(OH)D, PTH
Plan
| Supported by the Thrasher Research Fund and the General Clinical Research Center grant M01-RR00585 from the National Institutes of Health. |
Vol 149 - N° 6
P. 840-844 - décembre 2006 Retour au numéro
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