High accuracy of noninvasive tests to diagnose Helicobacter pylori infection in very young children - 09/08/11
Reprint requests: Prof. Giuseppina Oderda, Pediatric Department, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy.Résumé |
Objective |
To validate the 13C-urea-breath-test (UBT) and stool antigen test (HpSA) in children aged 5 years or younger, against invasive histologic study and rapid-urease-testing or culture.
Study design |
On all consecutive children aged 5 years or younger undergoing endoscopy in 1 single center during the last 7.5 years, UBT and HpSA were performed.
Results |
Of a total of 184 children (median age 2.2 years, range 0.2-5.5), 30 were Helicobacter pylori–positive (16.3%). Sensitivity and specificity of UBT were 93.3% (95%CI 77.9%-99.2%) and 95.5% (90.9-98.2), with a cutoff of 5‰, but specificity increased to 98.1% (94.4%-99.6%) with a cutoff of 8‰. Sensitivity and specificity of HpSA were 93.3% (77.9%-99.2%) and 98.7% (95.4%-99.8%).
Conclusion |
Accuracy of noninvasive tests in our single-center study were satisfactory: specificity of UBT improved with a cutoff at 8%, and sensitivity of HpSA was high when determined locally without transportation after long or inadequate storage that could impair results.
Le texte complet de cet article est disponible en PDF.Abbreviations : HpSA, OD, RUT, UBT
Plan
Vol 149 - N° 6
P. 817-821 - décembre 2006 Retour au numéro
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