Environmental exposures and exhaled nitric oxide in children with asthma - 09/08/11
, Richard Hornung, DrPH, Michelle Lierl, MD, Bruce P. Lanphear, MD, MPH
Reprint requests: Dr Adam Spanier, MLC 7035, 3333 Burnet Avenue, Cincinnati, OH 45229-3039.Résumé |
Objective |
To evaluate the relation of environmental factors with exhaled nitric oxide (FENO) concentrations among asthmatic children.
Study design |
Cross-sectional analysis of 170 tobacco smoke–exposed children, ages 6 to 12 years, who have doctor-diagnosed asthma using measures of FENO, medication use, and exposures to settled indoor allergens and tobacco smoke.
Results |
In multivariable analysis, child’s age, uncarpeted flooring, not owning a cat, higher income, dust mite exposure, and being sensitized to any allergens were associated with higher FENO concentrations. Children who were sensitized to indoor allergens had an adjusted geometric mean FENO of 15.4 ppb (95% CI, 13.1, 18.2) compared with 10 ppb (95% CI, 8.2, 12.2) for unsensitized children. There was no statistically significant association of serum cotinine, hair cotinine, or reported corticosteroid therapy with FENO.
Conclusions |
FENO is higher among children who are sensitized to indoor allergens and exposed to dust mites. The results hold promise for the use of FENO as a tool to manage childhood asthma by using both pharmacologic and environmental treatments.
Le texte complet de cet article est disponible en PDF.Abbreviations : ETS, FENO
Plan
| Supported by NHLBI R01-HL65731-01 and a National Research Service Award in Primary Care (5T32HP10027-07), funded by the HRSA Bureau of Health Professions, DHHS. |
Vol 149 - N° 2
P. 220-226 - août 2006 Retour au numéro
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