Neurocognitive findings in Prader-Willi syndrome and early-onset morbid obesity - 09/08/11
Reprint requests: Daniel J. Driscoll, PhD, MD, Pediatric Genetics, Box 100296, University of Florida College of Medicine, Gainesville, FL 32610-0296.Résumé |
Objectives |
To examine whether early-onset morbid obesity is associated with cognitive impairment, neuropathologic changes, and behavioral problems.
Study design |
This case-control study compared head MRI scans and cognitive, achievement, and behavioral evaluations of subjects with Prader-Willi syndrome (PWS), early-onset morbid obesity (EMO), and normal-weight sibling control subjects from both groups. Head MRI was done on 17 PWS, 18 EMO, and 21 siblings, and cognitive, achievement, and behavioral evaluations were done on 19 PWS, 17 EMO, and 24 siblings.
Results |
The mean General Intellectual Ability score of the EMO group was 77.4 ± 17.8; PWS, 63.3 ± 14.2; and control subjects, 106.4 ± 13.0. Achievement scores for the three groups were EMO, 78.7 ± 18.8; PWS, 71.2 ± 17.0; and control subjects, 104.8 ± 17.0. Significant negative behaviors and poor adaptive skills were found in the EMO group. White matter lesions were noted on brain MRI in 6 subjects with PWS and 5 with EMO. None of the normal-weight control subjects had these findings.
Conclusions |
Individuals with EMO have significantly lower cognitive function and more behavioral problems than control subjects with no history of childhood obesity. Both EMO and PWS subjects have white matter lesions on brain MRI that have not previously been described.
Le texte complet de cet article est disponible en PDF.Abbreviations : ANOVA, BASC, CGH, EMO, GIA, IBW, PKU, PWS, SES, UPD, WJ-III
Plan
| Support provided by National Institutes of Health grants 1K24 HD01361 (DJD), 2R01HD31491 (DJD) and 1U54 RR019478 (DJD, JLM and ALB); General Clinical Research Center M01 RR00082 from the National Center for Research Resources, University of Florida; Lawson Wilkins Pediatric Endocrine Society (JM); American Diabetes Association (AH); National Association for Autism (TS) and the Hayward Foundation (DJD). |
Vol 149 - N° 2
P. 192 - août 2006 Retour au numéro
Article précédent
- The association of maternal overweight and obesity with breastfeeding duration
- Wendy Hazel Oddy, Jianghong Li, Linda Landsborough, Garth Edward Kendall, Saras Henderson, Jill Downie
- Ghrelin levels in young children with Prader-Willi syndrome
- Christine R. Erdie-Lalena, Vanja A. Holm, Patrick C. Kelly, R. Scott Frayo, David E. Cummings
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