Childhood Predictors of the Metabolic Syndrome in Middle-Aged Adults: The Muscatine Study - 09/08/11
, Elena M. Letuchy, MS a, Richard Paulos, BS a, John Witt, BS a
Reprint requests: Dr Trudy L. Burns, 2199 WL, Department of Epidemiology, University of Iowa, Iowa City, IA 52242.Abstract |
Objective |
To investigate the association between components of the metabolic syndrome (MetS) measured during childhood/adolescence, and adult MetS.
Study design |
This investigation focused on members of the Muscatine Study Longitudinal Adult Cohort. Predictor variables were risk factor measurements obtained between 1970 and 1981 when cohort members participated in school survey examinations. Risk factor measurements obtained between 1982 and 2008 when cohort members participated in follow-up examinations as young and middle-aged adults were used for MetS classification.
Results |
33.0% (29.7% of 474 women; 37.0% of 384 men) of cohort members were classified as having the MetS. The initial MetS classification occurred at ages ranging from 23 to 52 years, with a mean age of 37.2 years (SD = 7.4). Cohort members with the MetS had significantly higher body mass index, systolic blood pressure, and triglycerides at the time they participated in the school survey examinations (P < .0001). Estimated probabilities of remaining MetS free at age 35 for those whose school survey body mass index and triglyceride measurements were both <50th vs ≥75th percentiles were strikingly different (0.94 vs 0.42).
Conclusions |
BMI is the strongest childhood predictor of adult MetS. Early identification of at-risk children may reduce the burden of atherosclerotic cardiovascular disease.
Le texte complet de cet article est disponible en PDF.Mots-clés : BMI, CHOL, FG, MetS, NCEP, NHANES, PMSWG, ROC, TRIG, WC, YAF
Plan
| Supported by research grant R01 HL061857 (TLB) from the National Heart, Lung and Blood Institute. This manuscript was prepared for the Pediatric Metabolic Syndrome Working Group. Its contents do not necessarily represent the views or policies of the National Institutes of Health. |
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| Please see the Author Disclosure section at the end of this article. |
Vol 155 - N° 3
P. S5.e17-S5.e26 - septembre 2009 Retour au numéro
Article précédent
- Patterns of Change in Cardiometabolic Risk Factors Associated with the Metabolic Syndrome among Children and Adolescents: The Fels Longitudinal Study
- Chaoyang Li, Earl S. Ford, Terry T.-K. Huang, Shumei S. Sun, Elizabeth Goodman
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- Christine M. Schubert, Shumei S. Sun, Trudy L. Burns, John A. Morrison, Terry T.-K. Huang
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