Effects of balloon-based distal protection during primary percutaneous coronary intervention on early and late infarct size and left ventricular remodeling: A pilot study using serial contrast-enhanced magnetic resonance imaging - 09/08/11
, Yeon Hyeon Choe, MD, PhD b, Il Rhee, MD a, Seung Hyuk Choi, MD, PhD a, Jin Ho Choi, MD, PhD a, Sang Hoon Lee, MD, PhD a, Kyong Pyo Hong, MD, PhD a, Jung Euy Park, MD, PhD aRésumé |
Background |
Distal protection devices are effective in preventing distal embolization during primary percutaneous coronary intervention (PCI). We investigated whether balloon-based distal protection could reduce early and late infarct size and left ventricular (LV) remodeling using serial analysis of contrast-enhanced magnetic resonance imaging (CE-MRI).
Methods |
Patients undergoing primary PCI for ST-segment elevation myocardial infarction within 12 hours after symptom onset were randomized to a distal protection group (n = 19) or to a control group (n = 20). The primary end point was infarct size evaluated by the volume of delayed hyperenhancement on CE-MRI at 3 days. The secondary end point included infarct size on CE-MRI at 6 months and LV remodeling assessed by the change between LV end-diastolic volume on CE-MRI at 3 days (baseline) and 6 months (follow-up).
Results |
Percutaneous coronary intervention procedures were fully protected with balloon-based distal protection in all patients of the protection group. Infarct size was similar in the distal protection group and the control group at baseline (25.9 ± 7.8% vs 26.1 ± 8.2%; P = .93) and at follow-up (21.4 ± 9.1% vs 18.5 ± 9.1%; P = .51). The change in LV end-diastolic volume was 10.5 ± 32.2 mL in the distal protection group and 8.9 ± 40.7 mL in the control group (P = .86). There was no significant difference in the 6-month rate of major adverse cardiac events between groups (none in the distal protection group and 4 patients in the control group; P = .11).
Conclusions |
Serial CE-MRI showed that the balloon-based distal protection during primary PCI did not reduce early and late infarct size or prevent LV remodeling.
Le texte complet de cet article est disponible en PDF.Plan
Vol 153 - N° 4
P. 665.e1-665.e8 - avril 2007 Retour au numéro
Article précédent
- Prognostic role of subclinical left ventricular abnormalities and impact of transplantation in chronic kidney disease
- Dhrubo J. Rakhit, Xiaohong H. Zhang, Rodel Leano, Kirsten A. Armstrong, Nicole M. Isbel, Thomas H. Marwick
- Epidemiology of angina pectoris: Role of natural language processing of the medical record
- Serguei S.V. Pakhomov, Harry Hemingway, Susan A. Weston, Steven J. Jacobsen, Richard Rodeheffer, Véronique L. Roger
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?