Cardiac power output predicts mortality across a broad spectrum of patients with acute cardiac disease - 09/08/11
, Julio A. Panza, MDRésumé |
Background |
Cardiac power output (CPO) is a novel hemodynamic measurement that represents cardiac pumping ability. The prognostic value of CPO in a broad spectrum of patients with acute cardiac disease undergoing pulmonary artery catheterization (PAC) has not been examined.
Methods |
Consecutive patients with a primary cardiac diagnosis who were undergoing PAC in a single coronary care unit were included. The relationship between initial CPO [(mean arterial pressure × cardiac output [CO])/451] and inhospital mortality was evaluated. CPO was analyzed both as a dichotomous variable (using a cutoff value previously established among patients with cardiogenic shock) and as a continuous variable.
Results |
Data were available for 349 patients. The mean CPO was 0.88 ± 0.37 W. The inhospital mortality rate was significantly higher among patients with a CPO ≤0.53 W (n = 53) compared with those with a CPO >0.53 W (n = 296) (49% vs 20%, P < .001). In separate multivariate analyses, both CPO and CO were associated with inhospital mortality. However, when both terms were included simultaneously, CPO remained strongly associated with mortality (odds ratio 0.63, 95% CI 0.43-0.91, P = .01), whereas CO did not (odds ratio 1.05, 95% CI 0.75-1.48, P = .78).
Conclusions |
Cardiac power output is a strong, independent predictor of inhospital mortality in a broad spectrum of patients with primary cardiac disease undergoing PAC.
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| This work was supported by the Cardiovascular Research Institute, Washington Hospital Center, Washington, DC. |
Vol 153 - N° 3
P. 366-370 - mars 2007 Retour au numéro
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