The relative value of metabolic syndrome and cardiovascular risk score estimates in premature acute coronary syndromes - 09/08/11
, Petros Tzimas, MD b, Christos S. Katsouras, MD a, John A. Goudevenos, MD, FACC, FESC a, Haralampos J. Milionis, MD bRésumé |
Background |
To compare the relative value of metabolic syndrome (MetS) and cardiovascular risk score estimates in patients with acute coronary syndromes (ACS) aged <45 years.
Patients and Methods |
Two hundred consecutive patients (183 men, mean age 40.8 ± 3.5 years) presented with a first-ever ACS, and 200 age-and sex-matched controls were evaluated. Metabolic syndrome diagnostic criteria, European Risk SCORE estimation function, and the Framingham Risk Score (FRS) were assessed in all participants.
Results |
The prevalence of the MetS was significantly higher in the patients' group compared with the control group (51.5% vs 26.0%, P < .001). No subjects with a SCORE >1.0% were identified. The mean 10-year FRS for patients and controls was 13.03% ± 7.96% and 10.02 ± 8.10%, respectively (P < .001), whereas only 22.5% of ACS patients had a 10-year risk >20.0% compared with 14.5% of controls (P = .04). After controlling for potential confounders, MetS was associated with 1.93 (95% CI 1.13-3.28, P = .01) higher odds of having an ACS. Moreover, the odds had a positive association with the increasing cumulative number of MetS components. Crude and adjusted ORs for the FRS were 1.05 (95% CI 1.029-1.08, P = .001) and 0.98 (95% CI 0.92-1.05, P = NS), respectively.
Conclusion |
Metabolic syndrome is highly associated with ACS in subjects <45 years of age and seems to be more valuable than established cardiovascular risk calculators.
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Vol 155 - N° 3
P. 534-540 - mars 2008 Retour au numéro
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