A comparison of the effectiveness of zanamivir and oseltamivir for the treatment of influenza A and B - 08/08/11
, Hideyuki Ikematsu a, b, ⁎, d , Norio Iwaki a, Tetsunari Maeda a, Hideo Kanazawa a, Takashi Kawashima a, Osame Tanaka a, Satoshi Yamauchi a, Kenichi Kawamura a, Toru Nagai a, Satsuki Horii a, Nobuo Hirotsu a, Seizaburo Kashiwagi c
Corresponding author. 4–9 Tonomachi, Gifu City 500-8116, Japan. Tel.: +81 58 245 0564; fax: +81 58 246 9057.Corresponding author.Summary |
Objective |
To compare the effectiveness of zanamivir with oseltamivir for influenza A and B.
Methods |
1113 patients with influenza A or B were enrolled in the 2006–2007 influenza season. The duration of fever (temperature, ≧37.5°C) and the percentage of patients afebrile at 24 and 48h after the first dose of zanamivir or oseltamivir were calculated. Virus persistence after zanamivir therapy was also evaluated.
Results |
There were marginally significant differences between the duration of fever after the first dose of zanamivir (31.8±18.4h) and oseltamivir (35.5±23.9h) for influenza A (p<0.05). The duration of fever after starting zanamivir therapy (35.8±22.4h) was significantly shorter than that of oseltamivir (52.7±31.3h) for influenza B (p<0.001). There were no significant differences between influenza A and B in the percentage of patients afebrile at 24 or 48h after the first inhalation of zanamivir. The reisolation rate after zanamivir therapy showed marginally significant differences between influenza A and B (<0.05). By multiple regression analysis, therapy (zanamivir or oseltamivir) was the major determinant affecting the duration of fever for influenza B.
Conclusion |
Zanamivir therapy is more effective than oseltamivir for the treatment of influenza B infection.
Le texte complet de cet article est disponible en PDF.Keywords : Influenza, Zanamivir, Oseltamivir, Virus isolation, Antigen detection test kits
Plan
Vol 56 - N° 1
P. 51-57 - janvier 2008 Retour au numéro
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