Identified cases of acute hepatitis C from computerized laboratory database: A hospital-based epidemiological and clinical study - 08/08/11
Summary |
Objective |
Diagnosis of acute hepatitis C (AHC) relies on documented positive-seroconversion of antibody to hepatitis C virus (anti-HCV) that is infrequently encountered. To clarify the epidemiology and clinical course of AHC, we tried to find more AHC patients from a computerized laboratory database by using a supplemental criterion of rising anti-HCV titer.
Methods |
All the computerized laboratory databases of anti-HCV and alanine aminotransferase (ALT) were reviewed. Candidates for AHC were identified by either anti-HCV positive seroconversion, rise of anti-HCV titer (signal to cut-off ratio (S/CO) ratio <40 to ≥40), or spontaneous HCV RNA clearance. AHC cases and their matched chronic hepatitis C controls were interviewed by a case–control study concerning risk factors.
Results |
AHC was identified in 123 patients (68 men and 55 women; median age: 48.4±13.9years), who had higher rates of recent surgery (p=0.037) and frequent injection therapy (p=0.036) compared to controls. Self-limited AHC was observed in 18 (19.1%, 95% confidence interval: 12.3–25.9%) of 94 AHC patients who had been followed for 6months, with a higher bilirubin level (≥2 vs. <2, p=0.007) compared to those evolved to chronic infection.
Conclusions |
Screening of a laboratory database for anti-HCV and ALT might uncover more AHC candidates to disclose the epidemiology and clinical course of AHC.
Le texte complet de cet article est disponible en PDF.Keywords : Acute hepatitis C, Anti-HCV titer, Seroconversion, Epidemiology, antiviral therapy
Plan
Vol 56 - N° 4
P. 274-280 - avril 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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