Utility of Bcl-2, P53, Ki-67, and Caveolin-1 Immunostaining in the Prediction of Biochemical Failure After Radical Prostatectomy in a Japanese Population - 08/08/11
, Nguyen Ba Phuoc, Masahiro Nakano, Hidetoshi Ehara, Naoki Yamamoto, Takashi Deguchi
Reprint requests: Takahiro Goto, M.D., Department of Urology, Gifu University Hospital, 1-1 Yanagido-Gifu-shi, Gifu-ken 501-1194, Japan.Résumé |
Objectives |
To identify predictive markers for biochemical failure after radical prostatectomy in patients with clinically confined prostate cancer.
Methods |
Immunohistochemistry of bcl-2, p53, Ki-67, and caveolin-1 was performed in samples of paraffin-embedded prostate cancer from 119 Japanese patients. The clinicopathologic significance of staining with these markers was analyzed in relation to biochemical failure (prostate-specific antigen [PSA] >0.2 ng/mL).
Results |
Univariate analysis showed the pretreatment PSA level (P = 0.03), postoperative Gleason score (P = 0.04), pathologic stage (P <0.001), seminal vesicle invasion (P <0.001), p53 staining (P <0.001), Ki-67 staining (P = 0.04), and caveolin-1 staining (P <0.0001) to be associated with biochemical failure. Multivariate Cox proportional hazards modeling showed that pretreatment PSA in group A (clinicopathologic parameters), caveolin-1 staining in group B, biomarkers, and the combination (group C) were independently associated with prediction of biochemical failure. The accuracy rate of each group was 76.2% (group A), 75.1% (group B), and 83.1% (group C), respectively.
Conclusions |
The combination of clinicopathologic parameters and biomarkers (group C) showed the highest accuracy rate. Caveolin-1 staining is an independent predictor of biochemical failure after radical prostatectomy.
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Vol 72 - N° 1
P. 167-171 - juillet 2008 Retour au numéro
Article précédent
- Prostatic Capsule and Seminal Vesicle-Sparing Cystectomy: Improved Functional Results, Inferior Oncologic Outcome
- Giuseppe Simone, Rocco Papalia, Costantino Leonardo, Rosario Sacco, Rocco Damiano, Salvatore Guaglianone, Ester Forastiere, Michelle Gallucci
- Natural History of Pathologically Organ-Confined (pT2), Gleason Score 6 or Less, Prostate Cancer After Radical Prostatectomy
- David J. Hernandez, Matthew E. Nielsen, Misop Han, Bruce J. Trock, Alan W. Partin, Patrick C. Walsh, Jonathan I. Epstein
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