Persistence of the Metabolic Syndrome Over 3 Annual Visits in Overweight Hispanic Children: Association with Progressive Risk for Type 2 Diabetes - 08/08/11
Reprint requests: Michael I. Goran, 2250 Alcazar Street, CSC 212, Los Angeles, CA 90089-2211.Abstract |
Objective |
To examine an association between persistent metabolic syndrome (MetS) and the risk for type 2 diabetes in overweight Hispanic children.
Study design |
A total of 73 subjects (mean age, 11.0 ± 1.7 years) from a longitudinal study were classified as Never (negative for MetS at all 3 annual visits), Intermittent (positive for MetS at 1 or 2 visits), or Persistent (positive for MetS at all 3 visits). Measures included dual-energy x-ray absorptiometry, magnetic resonance imaging, the 2-hour oral glucose tolerance test, and the frequently sampled intravenous glucose tolerance test.
Results |
The Persistent group had a faster rate of fat mass gain than the Never group (20% vs 15% gain of baseline value; P < .05 for timegroup interaction [time = visit]). Independent of body composition, the Persistent group increased by 70% in insulin incremental area under the curve, whereas the other groups decreased (P < .05 for timegroup interaction). Despite no timegroup interactions for insulin sensitivity, acute insulin response, or disposition index, the Persistent group maintained 43% lower insulin sensitivity (P < .01) and by visit 2 had a 25% lower disposition index (P < .05) compared with the Never group.
Conclusions |
Patients with persistent MetS had accelerated fat gain, increased insulin response to oral glucose, and decreased sensitivity and beta cell function, indicators of progressively greater risk for type 2 diabetes
Le texte complet de cet article est disponible en PDF.Mots-clés : AIR, ANCOVA, ANOVA, AUC, BMI, DEXA, DI, FSIVGTT, HDL, IAAT, IAUC, MetS, MRI, OGGT, SAAT, SI, SOLAR
Plan
| Supported by grants from the National Institutes of Health (R01 DK 59211), the General Clinical Research Center’s National Center for Research Resources (MO1 RR 00043), and the National Cancer Institute’s Center for Transdisciplinary Research on Energetics and Cancer (U54 CA 116848). |
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| The authors declare no conflicts of interest. |
Vol 155 - N° 4
P. 535 - octobre 2009 Retour au numéro
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