Cerebral and Splanchnic Hemodynamics after Duct Ligation in Very Low Birth Weight Infants - 07/08/11
Reprint requests: Dr M. E. Campbell, Neonatal Unit, 6th Floor North Wing, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UKRésumé |
Objective |
To describe mesenteric and cerebral blood flow velocities after surgical patent ductus arteriosus (PDA) closure in premature infants.
Study design |
We measured middle cerebral artery (MCA), celiac artery (CA), and superior mesenteric artery (SMA) Doppler ultrasound scanning blood flow velocity (BFV) preoperatively, 3 and 24 hours after ligation.
Results |
We studied 32 infants, with a mean (± SD) birthweight of 762 ± 170 g and gestational age of 25.6 ± 1.4 weeks at a mean age of 34 ± 13 days. Significant changes in end-diastolic (EDV), average velocity (AV), and vascular resistance were measured in all 3 vessels by 3 hours. AV increased significantly in the CA and SMA within 3 hours; however, no significant increase in MCA AV was found until 24 hours after surgery.
Conclusion |
PDA ligation significantly changes BFV in the MCA, CA, and SMA. In the MCA vascular tone is acutely modulated, with no change in AV at 3 hours. In the CA and SMA, AV increases acutely after ligation. These different patterns of change in BFV suggest region-specific adaptation to surgical PDA closure.
Le texte complet de cet article est disponible en PDF.Abbreviations : AV, BFV, CA, EDV, MCA, PDA, PI, PSV, RI, RM-ANOVA, SMA
Plan
| This work has not been sponsored or funded by any external organization, and the authors declare no conflict of interest. |
Vol 154 - N° 2
P. 196 - février 2009 Retour au numéro
Article précédent
- Randomized Trial of Milrinone Versus Placebo for Prevention of Low Systemic Blood Flow in Very Preterm Infants
- Mary Paradisis, Nick Evans, Martin Kluckow, David Osborn
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- Mary Pylipow, Logan G. Spector, Susan E. Puumala, Christopher Boys, Jessica Cohen, Michael K. Georgieff
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