Review of contemporaneous mycosis fungoides and B-cell malignancy at Mayo Clinic - 07/08/11
Reprint requests: David L. Swanson, MD, Department of Dermatology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259.Abstract |
Background |
Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other.
Objective |
We sought to determine whether the contemporaneous occurrence of the two malignancies is greater than chance and to investigate possible risk factors for the second malignancy.
Methods |
We retrospectively reviewed the records of patients with contemporaneous mycosis fungoides and B-cell lymphoma seen between 1990 and 2007 at Mayo Clinic, Rochester, MN, or at Mayo Clinic, Scottsdale, AZ.
Results |
In all, 23 patients had contemporaneous mycosis fungoides and B-cell malignancy. The first diagnosis was mycosis fungoides in 10 patients and B-cell lymphoma in 7; in 6 patients, the diseases were diagnosed simultaneously. No therapeutic factors could account for a predisposition to a second malignancy.
Limitations |
Retrospective design, referral center, and small sample size are limitations.
Conclusion |
Mycosis fungoides and B-cell lymphoma are unlikely to occur contemporaneously by chance, but no factor obviously predisposes a patient with one malignancy to development of the second
Le texte complet de cet article est disponible en PDF.Key words : B-cell lymphoma, cutaneous T-cell lymphoma, mycosis fungoides, Sézary syndrome
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 61 - N° 2
P. 271-275 - août 2009 Retour au numéro
Article précédent
- A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome
- Ingrid López-Lerma, Maria Teresa Estrach
- Positive staining of tumor-stage Kaposi sarcoma with lymphatic marker D2-40
- Meghan Dubina, Gary Goldenberg
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